Genome analysis with distance to the nearest dissimilar nucleotide

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Genome analysis with distance to the nearest dissimilar nucleotide.

DNA may be represented by sequences of four symbols, but it is often useful to convert those symbols into real or complex numbers for further analysis. Several mapping schemes have been used in the past, but most of them seem to be unrelated to any intrinsic characteristic of DNA. The objective of this work was to study a mapping scheme that is directly related to DNA characteristics, and that ...

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Genome analysis with inter-nucleotide distances

MOTIVATION DNA sequences can be represented by sequences of four symbols, but it is often useful to convert the symbols into real or complex numbers for further analysis. Several mapping schemes have been used in the past, but they seem unrelated to any intrinsic characteristic of DNA. The objective of this work was to find a mapping scheme directly related to DNA characteristics and that would...

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The normwise distance of a matrix A to the nearest singular matrix is well known to be equal to ‖A‖/cond(A) for norms being subordinate to a vector norm. However, there is no hope to find a similar formula or even a simple algorithm for computing the componentwise distance to the nearest singular matrix for general matrices. This is because Rohn and Poljak [7] showed that this is an NP -hard pr...

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ژورنال

عنوان ژورنال: Journal of Theoretical Biology

سال: 2011

ISSN: 0022-5193

DOI: 10.1016/j.jtbi.2011.01.038